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Sangamo Biosciences Licenses Maxcyte Cell Loading Technology for ZFP Therapeutic Program for Hiv/Aids

March 2, 2006

Gaithersburg, Maryland -– MaxCyte Inc., and Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today a license, option, development, and supply agreement to utilize MaxCyte's proprietary cell loading system for use in Sangamo's HIV/CCR5 ZFP Therapeutic program. The two companies have initiated a research and development plan to evaluate and further develop the GMP-compliant MaxCyte system to load zinc finger DNA-binding protein (ZFP)-based therapeutics into cells. Sangamo also has the option to utilize MaxCyte's system for ZFP Therapeutics in oncology.


The agreement provides Sangamo an option for a commercial license to MaxCyte's technology that includes a supply contract and clinical and commercial milestones to MaxCyte for products developed under the agreement. Under the license, Sangamo has the right to reference MaxCyte's FDA Master File in its regulatory submissions. Financial terms of the agreement were not disclosed.


"We believe MaxCyte's cell loading technology can be an important component of an ex vivo delivery system for our HIV T-cell program that uses ZFP nucleases (ZFN) to modify the gene for the CCR5 protein. A key part of our business model is to identify partners such as MaxCyte that have complementary delivery methods that can accelerate the clinical success of our programs and support their ultimate commercialization," said Edward Lanphier, President and CEO, Sangamo BioSciences, Inc.


"Preclinical data employing Sangamo's ZFN approach are encouraging, and we are excited about working with Sangamo to help move its HIV product into clinical trials. We're confident that the unmatched efficiency and scalability of our cell loading technology can have a positive impact on the clinical and commercial production of promising therapeutics such as Sangamo's," said Douglas Doerfler, President and CEO, MaxCyte Inc.


About MaxCyte


MaxCyte is a clinical-stage cell therapeutics company with a rapidly growing pipeline of partnered and internally developed therapeutic candidates. The Company's proprietary ex vivo cell loading technology overcomes critical obstacles, such as safety, scalability, and reproducibility, which are fundamental to successful cell-based therapies. MaxCyte has demonstrated the value of its versatile technology by building a pipeline of six partnered therapeutic programs in oncology, pulmonary, metabolic and infectious diseases as well as developing three drug candidates in collaboration with leading researchers: one in Phase I/II clinical trials for treatment of chronic lymphocytic leukemia and two preclinical solid tumor programs. The MaxCyte system has a FDA Master File in place at CBER.


For more information, visit http://www.maxcyte.com/

About Sangamo


Sangamo BioSciences, Inc. is focused on the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. The most advanced ZFP Therapeutic development programs are currently in Phase 1 clinical trials for evaluation of safety in patients with diabetic neuropathy and peripheral artery disease. Other therapeutic development programs are focused on macular degeneration, ischemic heart disease, congestive heart failure, neuropathic pain, and infectious and monogenic diseases. Sangamo's core competencies enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF) that can control gene expression and, consequently, cell function. Sangamo is also developing sequence-specific ZFP Nucleases (ZFN) for therapeutic gene modification as a treatment for a variety of monogenic diseases, such as sickle cell anemia, and for infectious diseases, such as HIV. Sangamo has established several Enabling Technology Agreements with companies to apply its ZFP Technology to enhance the production of protein pharmaceuticals. Research at Sangamo is partially funded by an Advanced Technology Program (ATP) grant awarded by the National Institute of Standards and Technology (NIST).


For more information about Sangamo, visit the company's web site at www.sangamo.com




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