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Cytox Awarded Innovate UK Funding for Stratification of Neurodegenerative Diseases

April 20, 2015

Oxford, United Kingdom - Cytox Ltd, (Cytox) an innovative developer of assays for risk assessment and prediction of dementia, is pleased to announce that, as part of a consortium, the company has been awarded funding by the UK’s innovation agency, Innovate UK, through the Collaborative Research and Development (CR&D) competition ND1: ‘Diagnosis, management and stratification’. The CR&D project award is almost Ł1.3m ($1.9m) out of a total project value of Ł1.8m ($2.6m), over three years.


The funding has been awarded to a UK consortium, comprising Cytox, as consortium lead, Dr Zsuzsanna Nagy (University of Birmingham), Professor John Hardy (University College London); Dr Valentina Escott-Price (University of Cardiff) will work as an expert consultant in statistical genetics to the project team. The project will evaluate and validate the clinical utility of a customized genetic variation (Single Nucleotide Polymorphism [SNP]) panel associated with the mTOR signalling and other pathways in Mild Cognitive Impairment (MCI). Dysregulation of the complex mTOR pathway has been identified as a risk factor for Alzheimer’s disease (AD); differentially expressed mTOR pathway genes may regulate key functions linked to AD risk.


“We are delighted to be awarded funding by Innovate UK for this project,” commented Dr. Richard Pither, CEO of Cytox, “There is heavy competition for such awards, so this funding represents external support for our research by an expert review team and confirms the potential of our proprietary data suggesting that an assessment of disease risk may be possible using a customised genetic variation (SNP) panel associated with mTOR signalling and other pathways. Dementia is now considered as one of the most important issues we face as the population ages, and is a Government target for action globally. The validation of this panel for future at risk individuals with MCI is a key goal for Cytox, with our eventual aim to work with pharma companies and clinicians to provide prognostic tests to stratify early MCI patients.”


MCI may be a prodromal state for AD and over half of these patients are at high risk of progression to AD. Current prognostic methods for AD are only 25-30% accurate in early MCI. The lack of validated biomarkers hampers clinical management of AD and the production of new therapies. This project will study prospectively, a large cohort of MCI patients to validate the proprietary genetic variation panel for dementia risk. Such a prognostic test is essential to enable meaningful clinical trials of emergent AD therapies. It is believed that mTOR dysregulation may also play a role as a risk factor in other dementia types and neurological diseases.


About Cytox Limited

For more about the mTOR pathway and its potential role in early identification of risk of dementia and Alzheimer’s disease, follow this link: www.cytoxgroup.com/information-for-editors


About Innovate UK

Innovate UK is the new name for the Technology Strategy Board – the UK’s innovation agency. Taking a new idea to market is a challenge. Innovate UK funds, supports and connects innovative businesses through a unique mix of people and programmes to accelerate sustainable economic growth. For further information visit: https://www.gov.uk/government/organisations/innovate-uk


About Collaborative R&D projects

As the UK’s innovation agency, one of the main roles of Innovate UK is to achieve business and economic growth for the UK. One way the organisation supports this is through funding innovative Collaborative Research and Development (CR&D) projects. Collaborative research and development (R&D) encourages businesses and researchers to work together on innovative projects in strategically important areas of science, engineering and technology – from which successful new products, processes and services can emerge, contributing to business and economic growth. Find out more about the CR&D programme here: https://www.gov.uk/innovation-get-details-about-innovate-uk-funding-competitions#collaborative-researchand-development





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